National Institute of Diabetes and Digestive and Kidney Disease publishes research in hemeproteins.

A report, 'Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation,' is newly published data in Blood. According to a study from the United States, "Ldb1 and erythroid partners SCL, GATA-1, and LMO2 form a complex that is required to establish spatial proximity between the [sz]-globin locus control region and gene and for transcription activation during erythroid differentiation. Here we show that Ldb1 controls gene expression at multiple levels."

"Ldb1 stabilizes its erythroid complex partners on [sz]-globin chromatin, even though it is not one of the DNA-binding components. In addition, Ldb1 is necessary for enrichment of key …